BioDan Sciences

Skin Testing Services


BioDan develops both non-animal human skin models and in vivo skin test models for dermatological drug development.

3D Bioprinted Human Skin Model – Non-Animal

BioDan Sciences’ bioprinted human skin test model features an innovative and well-differentiated epidermis with stratum corneum, a bilayer of reconstructed human epidermis and dermis cultured on a fibrin matrix. A dermal layer containing human collagen produced by fibroblasts and a basal membrane containing collagen VII is placed between the epidermal and dermal compartments.

Our model is capable of reproducing normal human skin and is therefore an ideal alternative to in vitro drug and vehicle screening. Human keratinocytes are obtained from healthy consenting donors through human biopsies. They are then expanded and cultured via a process allowing for differentiation to produce stratum corneum.

Our testing model has been developed in line with ECVAM standards and focuses on the development of the following test assays:

  • Percutaneous absorption for topical formulations and ingredients
  • Effects of UVA/UVB radiation for topical formulations and ingredients
  • In vitro skin corrosion studies for topical formulations and ingredients
  • In vitro skin irritation studies for topical formulations and ingredients
3D Bio Printed Human Skin Model – Non-Animal image
In Vivo Skin Test Model image
In Vivo Skin Test Model for Dermatological Drug Development

BioDan is a leader in the development of skin test models. We produce validated human skin test models of a number of both dermatological pathologies and normal healthy skin. Our murine models facilitate not only the tracking of the topical and systemic effects of tested molecules and vehicles but also the exploration of our existing knowledge of pathology bases.

Models

Our in vivo human skin test models include healthy and pathological skin for:

  • Psoriasis
  • Atopic Dermatitis
  • Hyperkeratosis
  • Lamellar Ichthyosis

Applications

  • Percutaneous absorption for topical formulations and ingredients
  • In vivo skin corrosion studies for topical formulations and ingredients
  • In vivo irritation studies for topical formulations and ingredients
  • Therapeutic efficacy for oral and topical formulations and ingredients